Evidence for Functional Release of Endogenous Opioids in the Locus Ceruleus during Stress Termination

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Evidence for functional release of endogenous opioids in the locus ceruleus during stress termination.

Endogenous opioids target noradrenergic locus ceruleus (LC) neurons and potently inhibit LC activity. Nonetheless, it has been difficult to demonstrate functional regulation of the LC-noradrenergic system by endogenous opioids because of the lack of effect of opiate antagonists. The present findings provide evidence that endogenous opioids regulate LC neuronal activity during the termination of...

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Our dynamic environment regularly exposes us to potentially life-threatening challenges or stressors. To answer these challenges and maintain homeostasis, the stress response, an innate coordinated engagement of central and peripheral neural systems is initiated. Although essential for survival, the inappropriate initiation of the stress response or its continuation after the stressor is termin...

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ژورنال

عنوان ژورنال: The Journal of Neuroscience

سال: 2001

ISSN: 0270-6474,1529-2401

DOI: 10.1523/jneurosci.21-13-j0001.2001